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Md. Mofizur Rahman

Md. Mofizur Rahman

Chief Advisor & Research Fellow

Postdoc | PhD

Biography

Dr. Md. Mofizur Rahman is an experienced researcher focusing on nanomedicine, pharmaceutical chemistry, lipid nanoparticles, and advanced drug delivery systems (DDS). He actively mentors researchers and oversees strategic innovation.

Teaching & Research Experience
Department of Pharmacy, Daffodil International University Assistant professor - 2019 – Present
Department of Pharmacy, Bangladesh University Assistant Professor - 2012 – 2019
Emergent Bio-engineering Materials Research Team, Nanomedicine and DDS Group, RIKEN, Japan Junior Research Associate - 2016 – 2019
Graduate School of Science and Engineering, Saitama University, Japan Monbukagakusho Honors Scholarship - 2016 – 2019
Emergent Bio-engineering Materials Research Team, RIKEN, Japan Visiting Researcher - 2016

Academic Degrees & Thesis Work

2025-Present
Postdoc

Pharmaceutical Chemistry — University of Kansas, KS, USA

2022-2025
Postdoc

Biomedical Engineering — Binghamton University, Binghamton, NY, USA

2016-2019
Doctor of Philosophy (PhD) in Material Science

Nanomedicine and Drug Delivery — Saitama University, Japan

Dissertation Title:

“Spontaneously Formed Higher-Order Architectures of Amphiphilic Polypeptides with Other Components”

Supervisors: Prof. Yoshihiro Ito & Prof. Takuji Hirose
2012
Master of Pharmacy (M.Pharm)

Pharmaceutical Technology — Khulna University, Bangladesh

Dissertation Title:

“Development & Characterization of fenofibrate solid dispersions and tablets: A Dissolution enhancement technique”

2010
Master of Science (M.S.) in Pharmaceutical Technology

Pharmacy — University of Asia Pacific, Dhaka, Bangladesh

Dissertation Title:

“Characterization & evaluation of sustained release matrix tablets for lamivudine using methocel K15M”

Publications & Preprints

1 Md. Mofizur Rahman, Jing Wang, Guosheng Wang, Zhipeng Su, Yizeng Li, Yundi Chen, Jinguo Meng, Yao Yao, Lefei Wang, Stephan Wilkens, Jifu Tan, Juntao Luo, Tao Zhang, Chuandong Zhu, Sung Hyun Cho, Lixue Wang, Luke P. Lee, and Yuan Wan. Chimeric nanobody-decorated liposomes by self-assembly. Nat. Nanotechnol. (2024). https://doi.org/10.1038/s41565-024-01620-6, Patent submitted.
2 Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md. Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee & Yuan Wan. Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles. Nat Commun., 2023, 14, 3366. https://doi.org/10.1038/s41467-023-39181-2.
3 Md. Mofizur Rahman, Lixue Wang, Md. Motiar Rahman, Yundi Chen, Wenlong Zhang, Jing Wang, Luke P. Lee, and Yuan Wan. Synthesis of palmitoylated nanobody anchored LNP for the delivery of SARS COV 2 mRNA to precisely target lung cancer. (Peer review)
4 Md. Mofizur Rahman, Lixue Wang, Md. Motiar Rahman, Yundi Chen, Wenlong Zhang, Jing Wang, Luke P. Lee, and Yuan Wan. Rapid in situ mutation detection in extracellular vesicle-DNA. bioRxiv, 2024 Feb 29:2024.02.26.582068. doi: 10.1101/2024.02.26.582068. PMID: 38464277; PMCID: PMC10925088.
5 Md. Mofizur Rahman, Lixue Wang, Md. Motiar Rahman, Yundi Chen, Wenlong Zhang, Jing Wang, Luke P. Lee, and Yuan Wan. Accurate and rapid in situ detection of mutation in extracellular vesicle by Cas12-loaded liposomes: CLIPS. (Under peer review)
6 Md. Mofizur Rahman, Motoki Ueda, Takuji Hirose, and Yoshihiro Ito. Spontaneous Formation of Gating Lipid Domain in Uniform-Size Peptide Vesicles for Controlled Release. J. Am. Chem. Soc. 2018, 140, 17956–17961. (US Patent, US 2020/0214981 A1)
7 Md. Mofizur Rahman, Motoki Ueda*, Kon Son, Siyoong Seo, Shinji Takeoka, Takuji Hirose, Yoshihiro Ito*. Tubular network formation by mixing amphiphilic polypeptides with differing hydrophilic blocks. Biomacromolecules, 2019, 20, 10, 3908-3914.
8 Md Mofizur Rahman, Mohammed Abdelhamid Ramadan Abosheasha, Yoshihiro Ito, Motoki Ueda. DNA-Induced Fusion between Lipid Domains of Peptide-Lipid Hybrid Vesicles. Chem. Commun., 2022, 58, 11799-11802.
9 Motoki Ueda, Stefan Müller, Siyoong Seo, Md. Mofizur Rahman, and Yoshihiro Ito. Integrated Nanostructures Based on Self-Assembled Amphiphilic Polypeptides. Advances in Bioinspired and Biomedical Materials, 2017, 1, 19–30, American Chemical Society.
10 Motoki Ueda, Md. Mofizur Rahman, Yoshihiro Ito. Phase-separated co-assembly between peptide and lipid and shifted phase transition temperature of lipid domain surrounded by peptides. Peptide Science 2019 (Preprint 56th JPS), Co-first author, publish Feb, 2020.
11 Md. Mofizur Rahman, Motoki Ueda, Takuji Hirose, and Yoshihiro Ito. Uniformed sized polysarcosine peptide-lipid hybrid vesicle enhanced cellular uptake by HeLa cell for intracellular delivery of drug. Manuscript under preparation.
12 Md. Mofizur Rahman, Sophia Hossain, Sanjida Haque, Md A K Azad, Md Monirul Islam and Nazneen Ahmeda Sultana. Fabrication and characterization of lipid based nano-particle of insulin for oral delivery: In-vitro-In-vivo evaluation. (Under peer review)
13 Md. Mominur Rahman, Afaf A. Aldahish, Asma M. Alshahrani, Md. Rezaul Islam, Md. Tanjimul Ahasan, Md. Noor Alam, Fahadul Islam, Nadia Sarkar, Md. Saidur Rahaman, Md. Mofizur Rahman, Saikat Mitra, Muniruddin Ahmed, Talha Bin Emran. Natural Small Molecules and Cancer Stem Cells: A Promising Therapeutic Strategy. (Under peer Review)
14 Md. Mofizur Rahman, Md AK Azad, Nishat Bahadur, Sujunur Rahman. Transdermal lymphatic delivery of scaffold insulin Xerogel using mice model. (Submitted).
15 Md. Mofizur. Rahman, Motoki Ueda, Takuji Hirose, Yoshihiro Ito. Spontaneous formation of gating lipid-domain in uniform-size peptide vesicle for control release. Peptide Science 2018, 2019, in press. (Preprint)
16 Md. Mofizur Rahman*, Mohammad Moniruzzaman, Sanjida Haque, Md A K Azad, Farjana Islam Aovi and Nazneen Ahmeda Sultana. Effect of Poloxamer on release of poorly water soluble drug, Loratadine from solid dispersion: Kneading method. Maced. pharm. bull., 61(1), 45-60, 2015.
17 Zilly Homa, Md. Qamru Ahsan, Md. Mofizur Rahman*, Mohammed Ibrahim, Nazneen Ahmeda Sultana, Sajida Haque, M. Mohi Uddin Chowdhury. Design, Development and In-vitro Evaluation of Amlodipine besylate Effervescent floating tablets by using different polymers. Pharm & Bio Eva, 2015; vol. 2 (5): 179-187.
18 Md. Abu Shuaib Rafshanjani, Md. Mofizur Rahman*, Shumaia Parvin, Md. Abdul Kader. Dissolution enhancement of glimepiride dispersion using glyceryl monostearate and β-cyclodextrin as carrier. Int. Curr. Pharm. J., 2015, 4(10): 436-441.
19 Md. Mofizur Rahman*, Md. Qamrul Ahsan, Abul Bashar Ripon Khalipha, Md. A K Azad, Nazneen Ahmeda Sultana, Sophia Hossain and Sanjida Haque. Formulation and In-Vitro Evaluation of Oral Sustained Release Drug Delivery System for Lamivudine Matrix Tablets Using Methocel K15M CR Polymer, 2014; 10 (24): 351-363.
20 Md. Mofizur Rahman*, Abul Bashar Ripon Khalipha, Md. A. K. Azad, Sophia Hossain & Sanjida Haque. Methods of solubility and dissolution enhancement for poorly water soluble drugs: A review. Wor. J Pharm and Pharm Sci. 2014, 3(5), 107-130.
21 Md. Qamrul Ahsan, Md. Mofizur Rahman, AKM Moyeenul Huq, Mohammad Ibrahim, Ishtiaq Ahmed, Abul Bashar Ripon Khalipha. Development and In-Vitro Evaluation of the Comparative study of Salbutamol Sulphate using Methocel K15M CR and Methocel K100M CR polymers for Sustained release matrix tablets. Inventi Impact: Pharm Tech, 2013; January-March(1): 1-6.
22 Md. Mofizur Rahman, Abul Bashar Ripon Khalipha, Md. A. K. Azad, Md. Zakaria Faruki, Amit K. Chaurasiya and Hemayet Hossain. Effect of natural and synthetic polymer on release of ketotifen fumarate matrix tablets: A sustained release dosage form. Int J Pharm Sci Res 2013; 4(4): 1401-1408.
23 Drishti Rani Ghosh, Rishikesh, Md. Anwarul Haque, Mst Rikta Banu, Mohammad Mahbubur Rahman, Md. Sium-Ul Hossain Miah, Md. Mofizur Rahman. Floating drug delivery system: A review. Journal of Drug Discovery and Therapeutics 1 (8) 2013, 52-59.
24 Mithilesh Kumar Jha, Md. Zakaria Faruki, Md. Habibur Rahman, Md. Mofizur Rahman, Md. Mesbah Uddin Talukder. Development and In-Vitro Evaluation of Vinpocetine Loaded Bi-Layer Tablet Using Different Polymers. J App Pharm Sci. 2012; 2 (12): 149-157.
25 Md. Mofizur Rahman, Abul Basar Khalpha, Amit Kumar Chaurasiya, Mithilesh Kumar Jha, Md. Qamrul Ahsan, Zakaria Faruki and Md. Jannatul Ferdaus. Synergistic Effects of Disintegrants on Release of poorly Water soluble drug. Int. J. Pharm. Lif. Sci., 2012; 1(3): 6; 1-18.
26 Md. Armin Minhaz, Md. Mofizur Rahman, Md. Qamrul Ahsan, Md. Habibur Rahman and Md. Raihanul Islam. Enhancement of solubility and Dissolution properties of clonazepam by solid dispersions. Int. J. of Pharm. & Life Sci. (IJPLS), 2012; 3(3): 1510-1518.
27 Md. Mofizur Rahman, Md. Armin Minhaz, Md. Qamrul Ahsan, Md. Abul Basher Ripon Kholipa and Mohammed Raihan Chowdhury. Dissolution enhancement of poorly soluble drug by solvent evaporation method using hydrophilic polymer: a solid dispersion technique. Int. j. pharm. life sci., 2012; 1(2); 2: 1-18.
28 Md. Mofizur Rahman, Md. Rezaul Karim, Md. Qamrul Ahsan, Abul Bashar Ripon Khalipha, Mohammed Raihan Chowdhury and Md Saifuzzaman. Use of computer in drug design and drug discovery: a review. Int. J. Pharm. Lif. sci., 2012; 1(2); 5: 1-18.
29 Md. Mofizur Rahman, Md. Qamrul Ahsan, Mithilesh Kumar Jha, Ishtiaq Ahmed, Md. Mizanur Rahman Moghal, Md. Habibur Rahman. Development and in-vitro evaluation of sustained release matrix tablets of salbutamol sulphate using methocel K100M CR polymer. IJPSR, 2011; Vol. 2(3): 567-576.
30 Md. Mofizur Rahman, Sumon Roy, Sreedam Das, Mithilesh Kumar Jha, Taslima Begum, Md. Qamrul Ahsan, Md. Shariful Islam, Md. Selim Reza. Evaluation of Various Grades of Hydroxypropylmethylcellulose Matrix Systems as Oral sustained release drug Delivery systems. J. Pharm. Sci. & Res., 2011; 3(1): 930-938.
31 Md. Mofizur Rahman, Sumon Roy, Sreedam Chandra Das, Md. Qamrul Ahsan, Md. Sadhin, and Md. Selim Reza. Formulation and evaluation of hydroxypropylmethylcellulose based matrix systems as oral sustained release drug delivery systems for ciprofloxacin hydrochloride. Int J. Pharm. Res & Rev, 2011; 6(2): 34-41.
32 Md. Mofizur Rahman, Mithilesh Kumar Jha, Md. Qamrul Ahsan and Taslima Begum. Effect of Various Grades of Hydroxypropylmethylcellulose Matrix Systems as Oral Sustained Release Drug Delivery Systems for Ranolazine. J. Pharm & Cos, 2011; 1(2): 81-92.
33 Md. Mofizur Rahman, Md. Qamrul Ahsan, Mithilesh Kumar Jha, Ishtiaq Ahmed, Md. Habibur Rahman. Effect of mannitol on release of lamivudine sustained release matrix tablets using methocel K15M CR polymer. Inventi Impact: Pharm Tech, 2010; 1(1): 1-5.
34 Md. Mofizur Rahman, Sayeed Hasan, Md. Ashiqul Alam, Sumon Roy, Md. Qamrul Ahsan and Md. Habibur Rahman. Formulation and evaluation of Ranolazine sustained release matrix tablets using Eudragit and HPMC. Int J Pharm Biomed Res, 2011; 2(1): 7-12.
35 Md. Mofizur Rahman, Sumon Roy, Sayeed Hasan, Md. Ashiqul Alam, Md. Qamrul Ahsan and Md. Jannatul Ferdaus. Effect of mode of addition of disintegrants on dissolution of model drug from wet granulation tablets. Int J. Pharm. Sci & Res, 2011; 2(2): 84-92.
36 Mithilesh Kumar Jha, Md. Mofizur Rahman and Md. Habibur Rahman. Biphasic Oral Solid Drug Delivery System: A Review. Int J Pharm Sci Res 2011; 2(5): 1109-1115.
37 Md. Mofizur Rahman, Abul Bashar Ripon Khalipha, Rishikesh, Md. Borhanuddin Opu, Md. Faqruddin. Formulation and In-Vitro Evaluation Of Ketotifen Fumarate Sustained Release Matrix Tablets Using HPMC 4000 cps (Methocel K4M CR) and Xanthan Gum (3:1). Int. J. Drug Dev., 2011; 3: 513-524.
38 M. Anwarul Islam, Md. Sarowar Hossain, Md. A.K. Azad, Md. Harun-Or Rashid, Md. Mofizur Rahman. In vivo evaluation of analgesic, anti-inflammatory and antidiabetic activities of methanol extract of Carallia brachiata l. Leaves. PharmacologyOnline. 1; 38-46: 2020.
39 Md. Ekramul Haque*, Md Mofizur Rahman, H. M. Shadid Hossain Snigdha. Evaluation of in vitro Anthelmintic and Antifungal activity of different organic extracts of the seeds of Aphanamixis polystachya (Wall.) Parker. Pharmacologyonline, 2020, 2, 281-292.
40 Md. Abdul Jalil, Nushrat Jahan, Md. Mohaiminul Islam, A.B. Ripon Khalipha, Chand Sultana Khatun, Md. Mofizur Rahman, Md. A.K. Azad. Analgesic and anti inflammatory activities of methanolic extract of fruit rind of citrullus lanatus (thunb). Int J Pharm 2015; 5(1):65-68.
41 Ohidul Islam, Rommanul Islam, Sweety Ritchil, Azizur Rahman, Mofizur Rahman, M. Moniruzzaman, Nandita Das, Chand Sultana, Sanjida Haque, A. K. Azad. Phytochemical screening and free radical scavenging activity of methanol extract of trigonella foenum-gracum (leaves). ejpmr, 2015, 2(6), 69-72.
42 S. M. Moazzem Hossen*, Jahidul Islam, S. M. Shakhawat Hossain, M. Mofizur Rahman and Firoj Ahmed. Phytochemical and Biological evaluation of MeOH extract of Casuarina equisetifolia (Linn.) Leaves, 2014; 4(8): 927-936.
43 Sheikh S, Sikder S, Paul SK, Hasan AMR, Rahaman MM and Kundu SP. Hypoglycemic, Anti-Inflammatory and Analgesic activity of Peperomea pellucida (L.) Hbk (Piperaceae). Int J Pharm Sci Res. 2013; 4(1): 458-463.
44 Mst Rikta Banu, Rishikesh, Drishti Rani Ghosh, Md. Anwarul Haque, Md. Mofizur Rahman. Antibacterial Bustle of Leaf Extract of Cassia Fistula. Scholars Journal of Applied Medical Sciences (SJAMS), Sch. J. App. Med. Sci., 2013; 1(4): 236-238.
45 Rishikesh, Md. Mofizur Rahman, Md. Zakaria Faruki, Sk- Moynul Hasan, Drishti Rani Ghosh, Md. Moshfiqur Rahman. Antimicrobial Behavior of Some Medicinal Plants Of Rangpur Division, Bangladesh. Int. Res J Pharm. App Sci., 2012; 2(6): 170-173.
46 Rishikesh, Md. Mofizur Rahman, Md. Zakaria Faruki, Md. Chhanaur Rabbee, Drishti Rani Ghosh, Sk Moynul Hasan. Phytochemicals and antimicrobial behavior of plant swertia chirayita, a medicinal plant from rangpur, Bangladesh. Int. Res J Pharm. App Sci., 2012; 2(6): 183-186.
47 Rishikesh, Rahman MM, Islam SMS and Rahman MM. Phytochemical Screening and In vitro Antimicrobial Investigation of the Methanolic Extract of Centella asiatica Leaves. Int J Pharm Sci Res, 2012; 3(9): 3323-3330.
48 Md. Sariful Islam Howlader, Md. Mofizur Rahman, Abul Bashar Ripon Khalipha, Firoj Ahmed and Md. Mustafizur Rahman. Antioxidant and Antidiarrhoeal Potentiality of Diospyros blancoi. International Journal of Pharmacology, 2012; 8: 403-409.
49 Md. Zakaria Faruki, Mithilesh Kumar Jha, Md. Mofizur Rahman, M. B. Alam, M.E.H. Mazumder and Md. Sohel Rana. In-vitro antioxidant and cytotoxic potential of calotropis procera (r. br.) root. Int. J. Pharm. Sci. & Res., 2011; 2(8): 2132-2135.

Areas of Instruction & Specialization

Physical chemistry
Organic Chemistry
Nanotechnology and drug delivery
Biomolecular chemistry
Industrial Technology
Chemical Delivery System (CDS)
Liposome Technology
Biotechnology